Fermat’s Last Theorem / modularity theorem (1994, 2001)
Poincare Conjecture (2003)
Classification of finite simple groups (2004)
Axiomatics
Parallel Postulate (1829-1868)
Gödel’s Incompleteness Theorems (1931)
Continuum Hypothesis (1940, 1963)
Solved and unimportant, but with an interesting anecdote
Hilbert’s 3rd Problem (Dehn Invariants, 1883-1900, first to be solved)
Four color theorem (1976)
Kepler conjecture and honeycomb conjecture (1998, 1999, Thomas Hales). (Update 2026-07-03: sphere packing in dimension 8 actually earned Maryna Viazovka the 2022 Fields Medal, due to connections the work has with quasimodular forms. See the original paper and coverage in Plus and Quanta.)
Unsolved
Goldbach Conjecture
Twin prime conjecture
Perfect numbers / Mersenne primes
Collatz Conjecture
Whether Euler-Mascheroni constant is rational / algebraic or not
Riemann Hypothesis
Ramsey numbers (R(5, 5), R(6, 6))
ABC Conjecture
Birch and Swinnerton-Dyer Conjecture
Update 2026-07-03: Added note on sphere packing in dimension 8.